Application of Platelet-rich fibrin for Acute Myocardial Infarction Treatment

                  - 國立屏東科技大學 許岩得 教授

                  - 高雄登羣動物醫院 林昇全 DVM. Ph.D.

Abstract

Acute myocardial infarct is a major high mortality cause in heart attacks. The aim of this study was to evaluate the repair of acute myocardial infarct damage following the implantation of platelet-rich fibrin (PRF) in a one-step procedure. We demonstrated the improvement of acute myocardial infarct damages with different concentrations of platelet-rich fibrin extract by direct-myocardial injections. Platelet-rich fibrin contains several growth factors mainly include platelet derivative growth factor (PDGF–A,B), transforming growth factor(TGF-β), vascular endothelial growth factor (VEGF) and epidermal growth factor(EGF). Platelet growth factors exhibit chemotactic and mitogenic properties that promote and modulate cellular functions involved in tissue healing, cell regeneration and cell proliferation. Platelet-rich fibrin extracts implantation for acute myocardial infarct show optimally in infarct area decrease and new angiogenesis. Fibrosis formation was unclear in myocardium infarct area. Heart function measurement demonstrated improvement of left ventricular ejection fraction (LVEF) and fraction shortening (FS) in platelet-rich fibrin extract groups.

Key Words: Acute myocardial infarct、 biomaterial 、 Growth factor 、heart attacks 、 Platelet-rich fibrin

附件